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Destination Death
Destination Death

Season 1, Episode 15 · 1 year ago

EP16 Medical Corner: Chimerism

ABOUT THIS EPISODE

"But I thought ligers weren't real" Intro by @benny_jets on instagram and follow the show @destinationdeathpodcast!

Wo and welcome too, or welcome back ifyou are on you. Today's episode is on a very cool topic. We are doing anothermedical corner. It's going to be a little bit shorter. It's a reallyreally cool and fun topic that I think a lot of people are aware of, but maybedon't believe that it actually exists. The topic of today is cimorism andCIMERAS are organisms that have cells from more than one species or more thanone individual, so the most well known Kimera is from Napoleon dynamite. It'sthe Liger, the idea that a tiger and a lion can be bred together to produce ahalf tiger. Half Lion Offspring CEMERAS can occur in nature, but theyare incredibly rare. It is not normal for species to breed with each other. Most Times theoffspring comes out with a lot of...

...issues. Any ligger that has ever been producedhas always been sterile. They're, just not meant for these things to happen,however, Cimaras can do not have to just be born.They are things that can be created so we'll get into that in a second, butfirst will hit up my disclaimer. The information in this podcast, as well asthose that follow, is information readily available on the Internet. I'vespent my own time researching these events and have included onlyinformation I deem necessary in describing the events to my audience.That being said, some information topics and opinions expressed from thispoint on could be considered explicit, grotesque and or offputding, so listenwith your own discretion, so human cimorism sounds kind ofterrifying having someone else's cells in your body, how exactly woat thatwork? And it's actually very easy, so we're going to go over. I think I havethree yeah. I have three different ways...

...that humans can become or are just born as Chimeras. The first one is sosimple: It is one that a lot of people don't think about the fact that you're getting anotherperson's cells during this process, but it's transplantation, so humans can receive another personcells simply by organ transplant. The definition of CIMERA is an organismwith sets of selves from War Than One distinct. Individual, so it doesn't saythat you have to be born that way. CIMORISM is a scary thought when it'sfirst brought up, but it is so widespread. I mean, if you think, aboutthe amount of people that have had organ transplants: Blood Transfusions, bone marrowtransplants, etc. Those people are all now chimaris. Now, in the case of bone Marro transplantation, all of thenew bloodcells made from that bone...

...marrow will be blood cells from theother individual. So you will be producing blood that is technicallysomeone else's blood. I hope that makes sense, but in the case of blood transfusion those cells turn over about every ahundred and twenty days. So after that period you no longer have those cellsin you, you just use them, as you know, extra blood for a littlewhile. So it's a little bit different when youget down to like the knittagrity of it. Obviously we know cell turnover. Soeventually, if you get a liver transplant, you won't have thatperson's liver cells anymore. You will recreate your own so but with bone marrow you're, a Khimeraforever you're always going to be...

...creating someone else's blood justinside your body, and that's how a lot of people that have leukemia made bloodtrinp, Blod Marrow Bone Mal. I so sorry, Bomao transfusions, bloom bone marrowtransplantation. Whatever you get it, those people will always be Kim Arosbecause they're always creating other people's blood, which is not infectedlike there's or cancerous. So the second is a lotmore widespread than transplantation is, but it is pregnancy. So every woman orperson that has ever given birth is a KIME era. It just comes with the withthe baby. It has been proven from an article that I read from two thousandand fifteen that stem cells from the fetus are transferred to the mother viathe placenta, and these stem cells can...

...actually circulate in the mother'sblood for decades. So if you have a mom which all of you do,you have made them a Kimera, they have some of your cells inside of themforever. Now a lot of people. I guess get a little bit confused bythis: stemsells have the ability to be turnedinto any kind of cell? That is why they are so valuable in treating disease,because you can literally put them anywhere and they will just adapt towhatever surrounding they're in and they will become whatever cell isneeded at that time in that place. So if the mother doesn't need the cells,they will just hang out, they have found a lot of them to kind of migrateto the brain, for whatever reason, so, a lot of mothers will have stemcells from their children inside their...

...brains. The cool thing about the pregnancy Kimera thing is stem, sells, have kind of an antitumoror anti cancer effect, meaning that, if you are a mother, you are solightlyless likely to get cancer than people who are non mothers slightly is the keyhere, though, the margin for this is so incredibly small, so I wouldn't get tooexcited about it. There are so many different things that go into who getscancer, and why and how? But you know, benefits of motherhood. Iguess these stem sells can also be used torepair any injuries the mother could receive. They can be used by the bodyfor maintenance and repair of vital structures. This technically pregnancycimorism is considered to be...

...microchimerism, because the actualamount of stem sells transferred is so incredibly small in comparison to theamount of cells in an adult human. So still pretty cool, though I think that it's cool twin absorption is the third one, and Ithink that people make jokes about this, a lot that people ate their twin in the womb. It's true, it's correct, you can eatabsorb your twin in the womb as odd as this phenomenon sounds. It's actually areally neat evolutionary happendance. I think that it's pretty cool, but Ithink that a lot of people would think that it was awful and orgross. So...

I apologize if you are one of thosepeople. So basically what happens at some point during gestation, onetwin will surpass or overtake the other, so this could be due to bloodflow.Maybe the second twin has kind of a rappt cord situation going on. Maybethey have some. You know chromasome deficiency, that's happening, that'scausing them not to properly jest ate anyway. At some point duringdevelopment, one twin will die in the womb or it will reach the phase ofbasically the same amount of cells dying as arebeing created. So it's kind of not moving at all. At this point, depending on howdeveloped the dominant twin is the dead feetust may just stick arounduntil birth, at which time it will be properly disposed of, or the dominanttwin might...

...decide. I mean it doesn't really makethe decision body kind of does that for them, but they might decide to use someof the structures that the other twin has already manufactured. Some people do have two different setsof DNA due to this phenomenon, so I think this. This is literallyincredibly rare, like this happens, like you know how I said earlier innature. This doesn't happen very often. This is like the very not often thingthat happens, so one woman in two thousand and two wasin and stage renal failure, desperately needed a kidney transplant and whenthey tested all of her family members, including her children, it wasdetermined that, based on DNA, her children could not have possibly beenher own children, but she was, she gave birth to them.She was present during their birth. She...

...has document sighing saying that she'stheir mom. So how does this happen right? Ther, Mida, candreal DNA did notmatch, ultimately, is what they tested. MIDACONDRIAL DNA for those that don'tknow, is passed from mother to offspring. So all of the Midrocondriald DNA that we have we were given from our mothers and their mothers beforethat and their mothers before that and Etca, etc. Etca, so her kids, might a condrial. DNAdoesn't match hers, but how was this possible if she gave birth to them? The answer to this is not simple at all,but I'm going to try to make it a little bit easier to understand. Sowhile she was in the womb, she had a twin and while her reproductive organs were beginningdevelopment, her twin died in the womb soinstead of using all of her energy toproduce her own reproductive organs.

Her body decided that they were just goingto take over the twin sisters, uterus andalso kidneys, so effectively absorbing the twin and using the uterus, the kidneys,possibly some other structures as well, so the children that she ultimatelygave birth to are actually her, never born dead, twinsisters, children. Ultimately, she did receive a rikkidney transplant, anserbu survived, but what a way to find out, you had asibling that never made it to birth because you ate them anyway. That is pretty much all I havefor you today. I hope that you enjoy this episode and I look forward totalking to you guys again soon once...

...again, if you could leave me a reviewon itunes or wherever you get your podcast from. That is how this showgets noticed. It's how we get to grow, and I like talking to you guys and givingyou all this information, but I think some of it is stuff that other peoplewould want to know to so share it with your friends. Leave me a rreview if youfeel like it, I'm not trying to pressure you, but I will talk to you guys later. I am comingwith the Valentine's Day special episode with myboyfriend on Alzheimer's. That will be later this week, not sure when that'scoming out, but thank you guys so much for your support and I hope you have agreat day night week. Whatever time it is where you're at Goodbye.

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